Applied Chemical Engineering

Preparations methods of tizanidine (API) and related compounds: A review

Korany A. Ali

National Research Centre

Eman Ali Ragab

Cairo University

DOI: https://doi.org/10.24294/ace.v6i1.1771

Keywords: Tizanidine, Drug Intermediates, Imidazoline Derivative, Drugs Synthesis

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Abstract

Tizanidine is an imidazoline derivative with the agonistic activity of central alpha 2 receptors at both the spinal and supra-spinal levels. It was prepared for the first time in 1978 and approved for use in 1996. The present review focuses on all methods used for the synthesis of tizanidine, related compounds and intermediates. This review article covers all the methods that have been used in the preparation of tizanidine since its discovery until now. Methods used for the preparation of tizanidine-related compounds are also covered. This review gives those interested in drug synthesis and designs the ability to form a complete picture of the preparation of this drug, as well as providing the opportunity for the synthesis of other drugs developed from this drug to increase activity and/or reduce side effects.

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Author Biography

Korany A. Ali, National Research Centre

Memberships

1-Member of the science alert (USA)
3-Member of Science Supercourse (Bibliotheca Alexandrina)
3- Member of Dove Medical Press
4-Member of the Egyptian Scientific Syndicate (1996-up to date)
5-Youth Researcher Association (2006-up to date)

Awards:
• National research centre encouragement award (NRC2015)
• Dr. Mahmoud Kamel Sedqy Award in Chemistry (NRC-2012).
• Excellence Award in research outputs (NRC-2013).
• Excellence Award in research outputs (NRC-2012).

Research Projects
1-National Research Center Project-[Principal Investigator]
Project Title: "New technique for blood preservation using modified biopolymer with anticoagulants (Project ID: 11030307) from 10/2016-11/2019
2-International project: Egypt - Russia Joint Cooperation Call (STDF - ERJCG)
Project Title: "Design of high-selective anticancer preparations on macrocyclic calixarene framework"(Project ID: 13840) from 10/2016-10/2018
3- STDF Project [CO-Principal Investigator]
Project Title: Treatment of Ground Water Using Environment-Friendly Cellulosic
Materials (Project ID: 15203) from 3/2016-3/2018

List of Publications:
1- Naglaa A. Abdel Hafez,و Mohamed A. Elsayed,aو Manal M. El-Shahawi, Ghada E. A. Awad, Korany A. Ali " Synthesis and Antimicrobial Activity of New Thiazolidine-Based Heterocycles as Rhodanine Analogues" J. Heterocyclic Chem.. (2018)
2- Korany A. Ali, Naglaa A. Abdel Hafez, Mohamed A. Elsayed, Manal M. Elshahawi, Salwa M. El-Hallouty, Abd El-Galil E. Am.
"Synthesis, Anticancer Screening and Molecular docking studies of New Heterocycles with Trimethoxyphenyl Scaffold as Combretastatin Analogues"
Mini-review in Medicinal chemistry, 2017, 17, DOI: 10.2174/1389557517666170425104241.
3- Naglaa A. Abdel Hafez, Korany A. Ali, Alhussein A. Ibrahim1, Dina H. Elnaggar, Amany A. Sleem. "Design, Synthesis and In-vivo Anti-inflammatory Activity of New Celecoxib Analogues as NSAID" Mini-review in Medicinal chemistry, 2017, 17.
4- Korany A. Ali, Grzegorz Mlostoń, Katarzyna Urbaniak, Anthony Linden and Heinz Heimgartner. "[3+2]-Cycloadditions of nitrilimines with heteroaryl Thioketones"
Journal of Sulfur Chemistry, 2017.37(2)
5- Anton Muravev, Alexei Laishevtsev, Farida Galieva, Olga Bazanova, Ildar, Korany A. Ali, Svetlana Solovieva, Igor Antipin, Alexander Konovalov, , Azide–alkyne Click Approach to the Preparation of Dendrimer-type Multi(thia)calix[4]arenes with Triazole Linkers. Macroheterocycles, 2017, 10(2) 203-214.
6- Nadia E.A. El-Gamel, Korany A. Ali, Synthesis, spectroscopic characterization, DFT calculations and biological evaluation of benzothiazole derivative bearing Mn(II) and Ni(II) metal ions, Journal of Molecular Structure 1147 (2017) 167e176.
7- Korany. A. Ali, Mohamed. E. Hassan, Magdy. M.M. Elnashar; "Development of functionalized carrageenan, chitosan and alginate, as polymeric chelating ligands for water softening "Int. J. Environ. Sci. Technol. 2017, 1-6, DOI 10.1007/s13762-017-1298.
8- Korany A. Ali, Abd El-Galil E. Amr and Khaled Mahmoud; Anticancer Activity of Some Synthesized of Mn(II), Cu(II),Ni(II), Sn(II) and Ca(II) Complexes Bis(3-phenylpropane-1,3-dione) Derivative as Ligand. Journal of Computational and Theoretical Nanoscience, 2017, 14, 1–4,
9- Osama I Abd El-Salam, Ali S Alsayed , Korany A. Ali, Ahmed A Abd Elwahab , Abd El-Galil E Amr, Ghada EA Awad "Antimicrobial activities of some newly synthesized substituted Benzosuberone and its related derivatives" Biomed Res- India 2017, 28 (1), 157-163.

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