Applied Chemical Engineering

Click chemistry: A fascinating, Nobel-winning method for the improvement of biological activity

Erkan Halay

Department of Chemistry and Chemical Processing Technologies, Banaz Vocational School, Usak University

Yaser Acikbas

Department of Materials Science and Nanotechnology, Faculty of Engineering, Usak University

DOI: https://doi.org/10.24294/ace.v6i1.1847

Keywords: Click Chemistry, Triazole, CuAAC, Cycloaddition, Drug Discovery, Biological Activity

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Abstract

Click chemistry is totally an approach consisting of efficient and reliable reactions that bind two molecular building blocks and require no complex purification techniques. The aspire of achieving molecules with the desired characteristics and behaviour is the key to the click chemistry concept. In this concept, in order to obtain 1,2,3-triazole products as diversely functionalized molecules, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has been widely used for years in the field of materials science, organic synthesis and the biochemistry. This review focusses on the importance of click chemistry for obtaining biologically active triazole molecules and therefore the applications of such 1,2,3-triazole derivatives in medicinal chemistry field are highlighted.

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Author Biography

Yaser Acikbas, Department of Materials Science and Nanotechnology, Faculty of Engineering, Usak University

Yaser  Acikbas ¸  received  his  BSc,  MSc  and  PhD  degrees  in  physics  from  the  University  of  Balikesir,  Turkey,  in  2003,  2006  and  2012,  respectively.  He  has  appointed as  an  assistant  professor  in 2013  and as associate professor from 2017 at  the  Department  of  Materials  Science  and Nanotechnology  Engineering  of  Usak  University  in  Turkey.  His research interests include fabrication of langmuir-blodgett (LB) thin films, chemical gas sensors based on organic nanomaterials, optical and swelling properties of nanothin films and materials science applications. 

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