Applied Chemical Engineering

Lipoproteins within the lymphatic system: Insights into health, disease, and therapeutic implications

Malaz Yousef

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta Edmonton

Nadia Bou Chacra

Faculty of Pharmaceutical Sciences, University of Sao Paulo

Neal M. Davies

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta Edmonton

Raimar Löbenberg

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta Edmonton

DOI: https://doi.org/10.24294/ace.v6i2.2202

Keywords: lymphatic, lipoproteins, chylomicrons, drug delivery, pathophysiology

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Abstract

This analysis of contemporary findings aims to enhance our understanding of lipoprotein biology within the lymphatic system and its relevance to human health and disease. It delves into the complex interrelationship between lipoproteins and the lymphatic system, encompassing their diverse classes and pivotal roles in the absorption and transport of drugs, vitamins, and xenobiotics. Lipoproteins consist of a hydrophobic core comprising non-polar lipids and a hydrophilic membrane composed of phospholipids, free cholesterol, and apolipoproteins. The lymphatic system collaborates with lipoproteins in the absorption and transport of dietary lipids. Simultaneously, it plays a vital role in the regulation of body fluid levels and acts as a formidable defense mechanism against infections. Lipoprotein classes encompass chylomicrons, chylomicron remnants, very low-density lipoproteins, intermediate density lipoproteins, low-density lipoproteins, high-density lipoproteins, and lipoprotein (a). Understanding the intricate relationship between lipoproteins and the lymphatic system holds immense implications for comprehending the underlying pathological processes of various diseases such as atherosclerosis, diabetes and obesity among others. By shedding light on the interplay between lipoproteins and the lymphatic system, this report underscores the significance of conducting research that contributes to the advancement of our knowledge in this field. Ultimately, such research paves the way for potential therapeutic interventions and novel strategies to address numerous disorders.

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