Applied Chemical Engineering

Exploring the potential of new ligand (-3-((4-(4-((-1,2-diphenyl-2-(thiazol-2-ylimino) ethylidene) amino) benzyl) phenyl) imino) butan-2-mono (PTIEABPBO) type imine-oxime complex with palladium (II) as an anticancer drug

Maysson Hussin Ali

Ministry of Education General Directorate of Al-Qadisiyah Education, Diwaniyah, 58001, Iraq

Mahmood Oudah mutashar

Ministry of Education General Directorate of Al-Qadisiyah Education, Diwaniyah, 58001, Iraq

Hussein Abed Al-Hasan

Department of Chemistry, College of Science, University of Al-Qadisiyah, Al Diwaniyah, Diwaniyah,,58001,Iraq

Hayder O. Jamel

Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, 58001, Iraq

DOI: https://doi.org/10.59429/ace.v8i2.5670

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Abstract

Herein, a new imine-oxime ligand was synthesized in a two-step reaction. In the  first step, 2-aminothiazole and benzil were reacted with glacial acetic acid as a catalyst resulting in the formation of 1,2-diphenyl-2-(thiazol-2-ylimino)ethan-1-one. In the second step, this intermediate was then reacted with diacetyl monoxime and 4,4'-methylenedianiline for synthesis of target ligand, PTIEABPBO. Afterwards, a palladium (II) complex of this ligand was also synthesized. Analyses of ligand and its complex were carried out via FT-IR, UV-Vis, and ¹H, ¹³C-NMR, analysis of melting point, elemental analysis, FESEM, and XRD. Findings of morphological study confirmed the purity of the synthesized compounds by demonstrating close agreement between calculated and experimental values. FT-IR highlights presence of azomethine and oxime bands in ligand, with shifts observed upon complexation with palladium. Crystallographic study indicated a crystalline, nanoscale structure for both compounds. Finally, biological evaluation demonstrated significant inhibitory activity of synthesized compounds against MCF-7 breast cancer cell line, when compared against HEK-293 normal cell line.

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