Applied Chemical Engineering

Synthesis of carbon nanoparticles from glucose, evaluation of their phenol adsorption capacity, and study their potential as drug delivery systems for treating human pancreatic cancer cells

Maram Ahmed Alaadin

Faculty of Production and Metallurgical Engineering, Department of Metallurgical Engineering, University of Technology, Baghdad, 10066, Iraq

Ghufran Ashour Hammood

Department of Chemistry, College of Science, University of Baghdad, Baghdad, 10071, Iraq

Sahar T. Adday

Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, 10071, Iraq

Amer Hamied Hussein

Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, 10071, Iraq

Anmar Haitham Nouri

Shaheed Mustafa Secondary School, Diyala Education Directorate, Baqubah, 32001, Iraq

DOI: https://doi.org/10.59429/ace.v8i3.5702

Keywords: carbon nanoparticles; phenol; drug delivery; MTT assay; pancreatic cancer; cytotoxicity

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Abstract

This research focuses on the synthesis of carbon nanoparticles from glucose through the wet chemical method. The dimensions of the generated particles were evaluated through XRD technology, and the capacity of the synthesized nanoparticles to adsorb phenol particles on their surface was illustrated using UV-VIS and FTIR analysis. The calculation of the loading efficiency (DLE) indicated a remarkably high ratio. The dimensions and morphology of the nanoparticles post-adsorption were assessed through Transmission Electron Microscopy (TEM), revealing the presence of tiny particles within the nanoscale range. To assess the cytotoxic effects on pancreatic cancer cells, various medication doses were prepared utilizing the MTT assay. The results indicate that the generated phenol-loaded nanoparticles exhibit significant potential in eradicating cancer cells.

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