Applied Chemical Engineering

Synthesis of new derivatives metochloro bromide drugs from 3-carboxy indole and evaluation of some their biological activities

Aya T. Abdulameer

College of Science for Women, University of Baghdad, Baghdad, 10071, Iraq

Sameaa J. Khammas

College of Science for Women, University of Baghdad, Baghdad, 10071, Iraq

DOI: https://doi.org/10.59429/ace.v8i3.5711

Keywords: metochloro bromide; biological activity; 3-carboxy indole

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Abstract

The discovery of new 2-Carboxy indole-based molecules with strong antibacterial properties remains a major emphasis in medicinal chemistry. In this study, a number of hybrid compounds (B1-B8) were created by functionalizing 2- Carboxy indole derivatives with a variety of heterocyclic frameworks such as benzothiazole and substituted aromatic groups. The synthesis process included several steps, including the manufacture of indole-3-carbonyl chloride, and condensation with potassium salts to produce gibberellin derivatives. The synthesized compounds were structurally confirmed using M.P (TLC), FT-IR, and NMR (¹H and ¹³C) spectroscopy. This study synthesized and characterized new indole-based derivatives using FT-IR and NMR methods. Several compounds demonstrated strong antibacterial and antifungal action, with compound B3 being the most effective. The structure-activity connection research found that electron-withdrawing groups increased activity, while bulky or electron-donating groups decreased it.

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