Applied Chemical Engineering

Synthesis and Characterization of Some New Drug Derivatives containing thiadiazole, oxadiazole, and triazole rings, and studying their antibacterial activity

Muntadher A. Al-Saffar

Department of Chemistry, College of Science, University of Babylon, Hilla 51001 Iraq

Shireen R. Rasool

Department of Chemistry, College of Science, University of Babylon, Hilla 51001 Iraq

Saba S. M. Al-Obaidy

Department of Chemistry, College of Science, University of Babylon, Hilla 51001 Iraq

DOI: https://doi.org/10.59429/ace.v8i4.5767

Keywords: Cephalexin; 4-aminobenzoic acid; thiadiazole; oxadiazole, triazole

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Abstract

A series of new drug derivatives containing thiadiazole, oxadiazole, and triazole rings were successfully synthesized. In this study, the terminal carboxylic acid groups of cephalexin and 4-aminobenzoic acid were reacted with thiosemicarbazide and semicarbazide, respectively, in the presence of phosphorus oxychloride to create the thiadiazole and oxadiazole derivatives. Cephalexin and 4-aminobenzoic acid's terminal carboxylic acid group reacted with thiosemicarbazide to create triazole derivatives, which were then treated with sodium hydroxide.The structures of the newly synthesized compounds were confirmed using IR, ¹H NMR, and ¹³C NMR spectroscopy. The antibacterial activity of these compounds was evaluated against Escherichia coli and Staphylococcus aureus

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