Applied Chemical Engineering

New spectrophotometric determination of salbutamol sulphate using p-methoxy aniline

Zahraa. R. Tameemi

Department of Chemistry, College of Science, Babylon University, Hilla 51002, Iraq,

Abbass. N.Alsirifi

Department of Chemistry, College of Science, Babylon University, Hilla 51002, Iraq,

Zahraa. H. Athab

Environmental Research and Studies Center, University of Babylon, Hilla51002,Iraq

DOI: https://doi.org/10.59429/ace.v9i2.5866

Keywords: p-methoxy aniline; spectrophotometry; Detection limit; coupling reactions

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Abstract

Salbutamol sulfate was analyzed using a straightforward, expeditious, and precise spectrophotometric approach. This method enabled the rapid and precise quantification of salbutamol sulfate within complex samples.in this method  Salbutamol sulfate is coupled with a diazotized p-methoxy aniline reagent in an alkaline medium to form stable and water- soluble yellow azo dye . The resulting compound exhibited maximum absorption at 426 nm The method follows Beer's law was over the concentration range 2-12 μg mL^-1 and Sandell's sensitivity index at 1.76 × 10^-2μg cm^-2, Detection limit is 0.0096 μg mL^-1. This approach demonstrates rising reliability (average recovery 98.75%), with a relative standard division (SD) is 0.0017 μg mL^-1 and molar absorption coefficient 3.269× 10⁴ L mol⁻¹ cm^-1.This proposed technique has been successfully applied to determine the salbutamol sulphate with no interference from conventional pharma logical excipients. Furthermore, this procedure was effectively versus the official ones, demonstrating its reliability and potential for routine analysis.

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