Applied Chemical Engineering

Influence of Fe3O4 ferrofluid medium Viscosity on local hyperthermic response for Cancer Therapy

Maan Al-Nuaim

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Basrah, Iraq

Hashim Jabbar

Department of Physics, College of Science, University of Basrah, Iraq

Sumaia H. Gatia

Department of Physics, College of Science, University of Basrah, Iraq

N. A. Abdullah

Department of Physics, College of Science, University of Basrah, Iraq

DOI: https://doi.org/10.59429/ace.v9i3.5954

Keywords: Fe3O4 nanoparticles; Co-precipitation; Ferrofluid; Viscosity; Magnetic hyperthermia; Cancer therapy

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Abstract

The fields of biotechnology and medicine are significantly impacted by the development of nanotechnology and associated materials.  Presently, a prominent subject in life sciences and healthcare is the application of magnetic nanoparticles (MNPs) owing to their size-variable physical and chemical characteristics.  Specifically, nanoparticles of iron oxide are being extensively studied to cure magnetic hyperthermia and provide very effective cancerous cell death. In this work, ferric and ferrous chloride were used as the starting precursors in coprecipitation process for producing magnetic Fe3O4 (NPs). Dynamic Light Scattering (DLS), Transmission Electron Microscopy, Field Emission Scanning Electron Microscopy (FE-SEM), Powder X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Vibrating Sample Magnetometer were utilized to analyze the produced NPs.  The results revealed that the NPs have spinal structure with a consistent size and a spherical shape.  According to the magnetic data, sample has a soft hysteresis loop, demonstrating their ferrimagnetic nature.  Furthermore, compared to the water medium, the magneto thermal response of Fe3O4 distributed in water/glycerol mixture exhibited 37% higher heat induction. These results highlights the importance of the medium viscosity in heat induction and medium of blood viscosity enhances the quantity of heat delivered, which is very promising result in hyperthermia for cancer therapy.

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