Applied Chemical Engineering

Synthesis, Characterization, Antioxidant and Antibacterial Activities of Benzimidazole Compounds

Waqar Ali jihad

Department of Chemistry, Collage of Education for pure Sciences, University of Karbala, Karbala 56001, Iraq

Alaa Jawad kadhim

Department of Chemistry, Collage of Education for pure Sciences, University of Karbala, Karbala 56001, Iraq

DOI: https://doi.org/10.59429/ace.v9i4.6082

Keywords: Benzimidazole, Azo, antioxidant, antibacterial

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Abstract

In this work, the synthesis of Azo compound [A1-A3] from different amines, was carried out and then converted to the 2-substituted benzimidazole compound [B1-B3], through the interaction of the resulting azo compounds with O-phenylenediamine. The structures of all new synthesized compounds were determined by FT-IR, 1H NMR and 13C NMR and their physicochemical properties, among them solubility, color, and melting point. The synthesized benzimidazole compounds were also evaluated for their antioxidant activity using the DPPH radical scavenging assay and for their antibacterial activity against selected Gram-positive and Gram-negative bacteria. The results demonstrated that the synthesized compounds exhibited antioxidant and antibacterial activities with different levels of activity among the tested compounds.

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