Applied Chemical Engineering

Use of sodium tetraphenyl boron for fabrication of potentiometric membrane sensor for the assay of olanzapine in pharmaceuticals and human urine

Rajendra Prasad Nagaraju

PG Department of Chemistry, JSS College of Arts, Commerce & Science, B N Road, Mysore 570001, Karnataka, India.

http://orcid.org/0000-0002-7746-6939

DOI: https://doi.org/10.24294/ace.v3i2.179

Keywords: Olanzapine, Membrane Sensor, Assay, Pharmaceuticals, Spiked Human Urine

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Abstract

Olanzapine (OLP), chemically known as 2-Methyl-10-(4-methyl-piperazin-1-yl)-4H-3-thia-4, 9-diaza-benzo[f]azulene, is an atypical antipsychotic drug. It is used for the treatment of schizophrenia and bipolar disorder. A new simple and selective membrane based potentiometric sensor was developed for potentiometric determination of olanzapine. The membrane was constructed using an ion-pair of OLP and sodium tetraphenyl boron in dioctyl phthalate and PVC. The membrane provides good linear Nernstian response covering relatively wide concentration range of 4 × 10^-6 - 1 × 10^-2 M OLP over pH range of 2.6 - 7.8. The detection limit for the developed sensor was founded as 2.02 × 10^-6 M. The response time of developed sensor is <10 s for the range of determination. The sensor showed good selectivity for OLP in the presence of various cations, anions and other organic molecules. The membrane was successfully applied in direct potentiometric determination of OLP in tablets. The percentage recovery of OLP, ranged from 96.2 to 99.68% with a mean standard deviation <5%, indicates the adoptability of sensor for the direct estimation of OLP in pharmaceuticals. The developed sensor was used to determine OLP in spiked human urine sample and the satisfactory results were obtained.

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References

[1] Basavaiah K, Rajendraprasad N, Vinay KB. Micro-titrimetric determination of drug content of pharmaceuticals containing olanzapine in non-aqueous medium. Chemical Industry and Chemical Engineering (Quarterly) 2009; 15: 77–81.

[2] Firdous S, Aman T, Nisa A. Determination of olanzapine by UV spectrophotometry and nonaqueous titration. Journal of Chemical Society of Pakistan 2005; 27: 163–167.

[3] Basavaiah K, Sameer AMA. Sensitive and selective methods for the determination of olanzapine in pharmaceuticals using n-bromosuccinimide and two dyes. International Journal of ChemTech Research 2010; 2: 660–668.

[4] Krebs A, Starczewska B, Puzanowsha-Tarasiewicz H, et al. Spectrophotometric determination of olanzapine with n-bromosuccinimide and cerium (IV) sulphate. Analytical Sciences 2006; 22: 829–833.

[5] Jasinska A, Nalewajko E. Batch and flow-injection methods for the spectrophotometric determination of olanzapine. Analytica Chimica Acta 2004; 508: 165–170.

[6] Rajendraprasad N, Basavaiah K, Tharpa K, et al. Quantitative determination of olanzapine in tablets with visible spectrophotometry using cerium (IV) sulphate and based on redox and complexation reactions. Eurasian Journal of Analytical Chemistry 2009; 4: 193–203.

[7] Rajendraprasad N, Basavaiah K. Highly sensitive spectrophotometric determination of olanzapine using Cerium (IV) and iron (II) complexes of 1,10-phenanthroline and 2,2’-bipyridyl. Journal of Analytical Chemistry 2010; 65: 482–488.

[8] Basavaiah K, Sameer AMA, Vinay KB. New extractive spectrophotometric methods for the determination of olanzapine in pharmaceutical formulatins using bromocresol green. Jordan Journal of Chemistry 2010; 5: 101–117.

[9] Rajendraprasad N, Basavaiah K. Determination of olanzapine by spectrophotometry using permanganate. Brazilian Journal of Pharmaceutical Sciences, 2009; 45: 539–550.

[10] Basavaiah K, Tharpa K, Rajendraprasad N, et al. Spectrophotometric determination of antipsychotic drug olanzapine in pharmaceuticals. Jordan Journal of Chemistry 2009; 4: 65–76.

[11] Mohamed AA. Kinetic and maximum-absorbance spectrophotometric methods for the determination of olanzapine. Monatshefte für Chemie - Chemical Monthly 2008; 139: 1005–1010.

[12] Raggi MA, Casamenti G, Mandrioli R, et al. Quantification of olanzapine in tablets by HPLC, CZE, derivative spectrometry and linear voltammetry. Journal of Pharmaceutical and Biomedical Analysis 2000; 23: 973–981.

[13] Patel R.B, Patel MR, Bhatt KK, et al. Development and validation of an HPTLC method for determination of olanzapine in formulations. Journal of AOAC International 2010; 93: 811–819.

[14] Shah CR, Suhagia BN, Shah NJ, et al. Stability-indicating simultaneous HPTLC method for olanzapine and fluoxetine in combined tablet dosage form. Indian Journal of Pharmaceutical Scienc-es 2008; 70: 251–255.

[15] Patel S, Patel NJ. Simultaneous RP-HPLC and HPTLC estimation of fluoxetine hydrochloride and olanzapine in tablet dosage forms. Indian Journal of Pharmaceutical Sciences 2009; 71: 477–480.

[16] Olesen OV, Linnet K. Determination of olanzapine in serum by high-performance liquid chromatography using ultraviolet detection considering the easy oxidizability of the compound and the presence of other psychotropic drugs. Journal of Chromatography B: Biomedical Science Applications 1998; 714: 309–315.

[17] Weigmann H, Härtter S, Sabine M, et al. Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by online column-switching high-performance liquid chromatography. Journal of Chromatography B 2001; 759: 63–71.

[18] Olesen OV, Poulsen B, Linnet K. Fully automated online determination of olanzapine in serum for routine therapeutic drug. Therapeutic Drug Monitoring 2001; 1: 51–55.

[19] Concetta D, Gaetana M, Vincenza S, et al. Determination of olanzapine in human-plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. Therapeutic Drug Monitoring 2006; 28: 388–393.

[20] Dusci LJ, Hackett LP, Fellows LM, et al. Determination of olanzapine in plasma by high-performance liquid chromatography using ultraviolet absorbance detection. Journal of Chromatography B 2002; 773: 191–197.

[21] Raggi MA, Casamenti G, Mandrioli R, et al. A sensitive high-performance liquid chromatographic method using electrochemical detection for the analysis of olanzapine and desmethylolanzapine in plasma of schizophrenic patients using a new solid-solid phase extraction procedure. Journal of Chromatography B; 2001; 750: 137–146.

[22] Raggi MA, Casamenti G, Mandrioli R, et al. Determination of the novel antipsychotic drug olanzapine in human plasma using HPLC with amperometric detection. Chromatographia 2000; 51: 562–566.

[23] Raggi MA, Mandrioli R, Sabbioni C, et al. Determination of olanzapine and desmethylolanzapine in the plasma of schizophrenic patients by means of an improved HPLC method with amperometric detection. Chromatographia 2001; 54: 203–207.

[24] Saracino MA, Koukopoulos A, Sani G, et al. Simultaneous high-performance liquid chromatographic determination of olanzapine and lamotrigine in plasma of bipolar patients”, Therapeutic Drug Monitoring 2007; 29: 773–780.

[25] Eap CB, Veuthey JL, Guillarme D, et al. Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS. Journal of Pharmaceutical and Biomedical Analysis 2009; 50: 1000–1008.

[26] Josefsson M, Roman M, Skogh E, et al. Liquid chromatography/tandem mass spectrometry method for determination of olanzapine and n-desmethylolanzapine in human serum and cerebrospinal fluid. Journal of Pharmaceutical and Biomedical Analysis 2010; 53: 576–582.

[27] Saracino MA, Gandolfi O, Dall’Olio RO, et al. Determination of olanzapine in rat brain using liquid chromatography with coulometric detection and a rapid solid-phase extraction procedure. Journal of Chromatography A 2006; 1122: 21–27.

[28] Kasper SC, Mattiuz EL, Swanson SP, et al. Determination of olanzapine in human breast milk by high-performance liquid chromatography. Journal of Chromatography B 1999; 726: 203–209.

[29] Xia X, Tao Z. Determination of olanzapine and its tablets by HPLC. Chinese Journal of Pharmaceuticals 2004; 35: 46–48.

[30] Pathak A, Rajput SJ. Development of stability-indicating hplc method for simultaneous deter-mination of olanzapine and fluoxetine in combined dosage forms. Journal of Chromatographic Sciences 2009; 47: 605–611.

[31] Reddy BV, Suresh Reddy KVN, Sreeramulu J, et al. Simultaneous determination of olanzapine and fluoxetine by HPLC. Chromatographia 2007; 66: 111–114.

[32] Shah CR, Shah NJ, Suagia BN, et al. Simultaneous assay of olanzapine and fluoxetine in tablets by column high-performance liquid chromatography and high-performance thin-layer chromatography. Journal of AOAC International 2007; 90: 1573–1578.

[33] Hiriyanna SG, Basavaiah K, Goud PSK, et al. Identification and characterization of olanzapine degra-dation products under oxidative stress conditions. Acta Chromatographica 2008; 20: 81–93.

[34] Ensafi A, Allafchian AR. Novel and selective potentiometric membrane sensor for amiloride determination in pharmaceutical compounds and urine. Journal of Pharmaceutical and Biomedical Analysis 2008; 47(4-5): 802–806.

[35] Kanberoglu GS, Coldur F, Topcu C, et al. A Flow-injection potentiometric system for selective and sensitive determination of serum lithium level. IEEE Sensors Journal 2015; 15(11): 6199–6207.

[36] AlRabiah H, Al-Majed A, Abounassif M, et al. Two novel potentiometric sensors for determination of clonidine in some pharmaceutical formulation. International Journal of Electrochemical Science 2016; 11: 6761–6774.

[37] Ganjali MR, Karimi S, Shahtaheri SJ, et al. Determination of clonidine by potentiometry using PVC membrane electrode. International Journal of Electrochemical Science 2013; 8: 1999–2008.

[38] Del Valle EM. Cyclodextrin and their uses a review. Process Biochemistry 2004; 39: 1033–1046.

[39] Hedges AR. Industrial applications of cyclodextrins. Chemical Reviews 1998; 98: 2035–2044.

[40] Yang R, Li K, Wang K, et al. Porphyrin assembly on β-cyclodextrin for selective sensing and detection of a zinc ion based on the dual emission fluorescence ratio. Analytical Chemistry 2003; 75: 612–621.

[41] El-Kosasy AM, Nebsen M, El-Rahman MKA, et al. Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide. Talanta 2011; 85(2): 913–918.

[42] Trojanowicz M. Enantioselective electrochemical sensors and biosensors: A mini-review. Electrochemistry Communications 2014; 38: 47–52.

[43] Patil SR, Turmine M, Peyre V, et al. Study of β-cyclodextrin/fluorinated trimethyl ammonium bromide surfactant inclusion complex by fluorinated surfactant ion selective electrode. Talanta 2007; 74: 72–77.

[44] El-Kosasy AM. Determination of hydroxyurea in capsules and biological fluids by ion-selective potentiometry and fluorimetry. Journal of AOAC International 2003; 86: 15–21.

[45] Ozoemena KI, Stefan RI. Enantioselective potentiometric membrane electrodes based on alpha-, beta- and gamma-cyclodextrins as chiral selectors for the assay of L-proline. Talanta 2005; 66: 501–504.

[46] IUPAC Analytical Chemistry Division. Recommendation for nomenclature of ion selective electrode. Pure and Applied Chemistry 1994; 66: 2527–2536.

[47] IUPAC Analytical Chemistry Division. Potentiometric selectivity coefficients of ion selective electrodes. Pure and Applied Chemistry 2000; 72: 1851–2082.