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editor-in-chief

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Prof. Sivanesan Subramanian

Anna University, India

 

Prof. Hassan Karimi-Maleh

University of Electronic Science
and Technology of China (UESTC)

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Home > Archives > Vol 6, No 3 (Published) > Original Research Article
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2023-10-12

Issue

Vol 6, No 3 (Published)

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Original Research Article

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How to Cite

Niccolai, N., Trezza, A., Marchini, F., Bongini, P., Bianchini, M., Santucci, A., … Visibelli, A. (2023). Omicron variants of SARS CoV-2 indicate a new antiviral strategy: interfering with spike glycoprotein trimerization. Applied Chemical Engineering, 6(3). Retrieved from https://ace.as-pub.com/index.php/ACE/article/view/2325
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Omicron variants of SARS CoV-2 indicate a new antiviral strategy: interfering with spike glycoprotein trimerization

Neri Niccolai

Department of Biotechnology, Chemistry and Pharmacy, University of Siena; Le Ricerche del BarLume Free Association, Ville di Corsano, Monteroni d’Arbia

Alfonso Trezza

Department of Biotechnology, Chemistry and Pharmacy, University of Siena

Federico Marchini

Department of Biotechnology, Chemistry and Pharmacy, University of Siena

Pietro Bongini

Department of Information Engineering and Mathematics, University of Siena

Monica Bianchini

Department of Information Engineering and Mathematics, University of Siena

Annalisa Santucci

Department of Biotechnology, Chemistry and Pharmacy, University of Siena; Industry 4.0 Competence Center ARTES 4.0 Viale Rinaldo Piaggio

Ottavia Spiga

Department of Biotechnology, Chemistry and Pharmacy, University of Siena; Industry 4.0 Competence Center ARTES 4.0 Viale Rinaldo Piaggio

Anna Visibelli

Department of Biotechnology, Chemistry and Pharmacy, University of Siena



Keywords: SARS-CoV-2, Omicron variants, sequence variability, spike glycoprotein, structure disassembly, interfering ligands


References

1. Miljanovic D, Cirkovic A, Lazarevic I, et al. Clinical efficacy of anti-SARS-CoV-2 monoclonal antibodies in preventing hospitalisation and mortality among patients infected with Omicron variants: A systematic review and meta-analysis. Reviews in Medical Virology 2023; 33(4): e2439. doi: 10.1002/rmv.2439

2. Zhou Y, Wang H, Yang L, Wang Q. Progress on COVID-19 chemotherapeutics discovery and novel technology. Molecules 2022; 27(23): 8257. doi: 10.3390/molecules27238257

3. Zhan W, Tian X, Zhang X, et al. Structural study of SARS-CoV-2 antibodies identifies a broad-spectrum antibody that neutralizes the omicron variant by disassembling the spike trimer. Journal of Virology 2022; 96(16): e0048022. doi: 10.1128/jvi.00480-22

4. Bongini P, Trezza A, Bianchini M, et al. A possible strategy to fight COVID-19: Interfering with spike glycoprotein trimerization. Biochemical and Biophysical Research Communications 2020; 528(1): 35–38. doi: 10.1016/j.bbrc.2020.04.007

5. Delmas B, Laude H. Assembly of coronavirus spike protein into trimers and its role in epitope expression. Journal of Virology 1990; 64(11): 5367–5375. doi: 10.1128/JVI.64.11.5367-5375

6. Sievers F, Wilm A, Dineen D, et al. Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Molecular Systems Biology 2011; 7: 539. doi: 10.1038/msb.2011.75

7. Bakan A, Dutta A, Mao W, et al. Evol and ProDy for bridging protein sequence evolution and structural dynamics. Bioinformatics 2014; 30(18): 2681–2683. doi: 10.1093/bioinformatics/btu336

8. Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020; 367(6483): 1260–1263. doi: 10.1126/science.abb2507

9. Krissinel E, Henrick K. Inference of macromolecular assemblies from crystalline state. Journal of Molecular Biology 2007; 372(3): 774–797. doi: 10.1016/j.jmb.2007.05.022

10. Koebel MR, Schmadeke G, Posner RG, Sirimulla S. AutoDock VinaXB: Implementation of XBSF, new empirical halogen bond scoring function, into AutoDock Vina. Journal of Cheminformatics 2016; 8(1): 27. doi: 10.1186/s13321-016-0139-1

11. Wishart DS, Feunang YD, Guo AC, et al. DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Research 2018; 46(D1): D1074–D1082. doi: 10.1093/nar/gkx1037

12. Magazine N, Zhang T, Wu Y, et al. Mutations and evolution of the SARS-CoV-2 spike protein. Viruses 2022; 14(3): 640. doi: 10.3390/v14030640

13. Mistry P, Barmania F, Mellet J, et al. SARS-CoV-2 variants, vaccines, and host immunity. Frontiers in Immunology 2022; 12: 809244. doi: 10.3389/fimmu.2021.809244

14. Alkhatib M, Salpini R, Carioti L, et al. Update on SARS-CoV-2 omicron variant of concern and its peculiar mutational profile. Microbiology Spectrum 2022; 10(2): e0273221. doi: 10.1128/spectrum.02732-21

15. Gurung AB, Ali MA, Lee J, et al. The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp. Saudi Journal of Biological Sciences 2021; 28(2): 1426–1432. doi: 10.1016/j.sjbs.2020.11.078

16. Kemp SA, Collier DA, Datir RP, et al. Author correction: SARS-CoV-2 evolution during treatment of chronic infection. Nature 2022; 608(7922): E23. doi: 10.1038/s41586-022-05104-2

17. Araf Y, Akter F, Tang YD, et al. Omicron variant of SARS-CoV-2: Genomics, transmissibility, and responses to current COVID-19 vaccines. Journal of Medical Virology 2022; 94(5): 1825–1832. doi: 10.1002/jmv.27588

18. Farheen S, Araf Y, Tang YD, Zheng C. The Deltacron conundrum: Its origin and potential health risks. Journal of Medical Virology 2022; 94(11): 5096–5102. doi: 10.1002/jmv.27990



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